Air Pollution Is Slowly Killing Us All, New Global Study ClaimAir pollution may be damaging every organ and virtually every cell in the human body, according to a comprehensive new global review, with 8.8 million deaths per year, double earlier estimates

Air pollution may be the greatest environmental risk to health in the world.1 According to the Global Burden of Disease estimates, one component of ambient (or outdoor air) pollution, fine particulate matter, or particulate matter with an aerodynamic diameter < 2.5 μm (PM2.5), is the fifth leading risk factor for death in the world, accounting for 4.2 million deaths (7.6% of total global deaths) and > 103 million disability-adjusted life years lost in 2015. Exposure to ambient ozone (O3) caused an additional 254,000 deaths,2 and estimates based on other statistical techniques set these numbers even higher.3 The World Health Organization reported that indoor air pollution from fires for cooking and heating accounted for 3.8 million deaths; this number ranged from 10% in low- and middle-income countries to 0.2% in high-income countries.4 In almost all cases, the greatest affliction of air pollution falls on the vulnerable population.

Air pollution may be associated with symptoms immediately upon exposure, such as coughing, tearing, difficulty breathing, and angina. It may also be associated with long-term harm that is more subtle. People are usually unaware of how long-term exposure affects their health or worsens their medical problems over time. Polluted air gains access to the body through the respiratory tract but has systemic effects that can damage many other organs.

The main purpose of these two papers is to review the available evidence to support the hypothesis that air pollution affects many organs beyond the lungs. The review omits infectious diseases and tobacco smoke exposure, and it generally does not distinguish between ambient and indoor (household) air pollution, although they can have very different compositions. Tobacco smoke could be considered a form of high-dose air pollution. There are similarities between tobacco smoke and air pollution in how they injure the body; in addition, their harmful health effects become increasingly similar as the toxicity and dosages of the inhaled materials become more alike. However, the lung disease resulting from exposure to indoor smoke has more bronchitic elements and fewer emphysematous elements than tobacco smoking.5 In Part 1 of this report, we review the mechanisms and multisystem health effects of air pollution in general and among vulnerable populations. In Part 2,6 we review the evidence for air pollution’s effects on individual organ systems.

May 17th, 2019 by  on Clean Technica

A comprehensive global study by the International Respiratory Society’s Environmental Committee and published recently in CHEST, the official publication of the American College of Chest Physicians, claims that air pollution may be damaging every organ and virtually every cell in the human body. Here’s the executive summary of the report.

Air pollution poses a great environmental risk to health. Outdoor fine particulate matter (particulate matter with an aerodynamic diameter < 2.5 μm) exposure is the fifth leading risk factor for death in the world, accounting for 4.2 million deaths and > 103 million disability-adjusted life years lost according to the Global Burden of Disease Report. The World Health Organization attributes 3.8 million additional deaths to indoor air pollution.

Air pollution can harm acutely, usually manifested by respiratory or cardiac symptoms, as well as chronically, potentially affecting every organ in the body. It can cause, complicate, or exacerbate many adverse health conditions. Tissue damage may result directly from pollutant toxicity because fine and ultrafine particles can gain access to organs, or indirectly through systemic inflammatory processes.

Susceptibility is partly under genetic and epigenetic regulation. Although air pollution affects people of all regions, ages, and social groups, it is likely to cause greater illness in those with heavy exposure and greater susceptibility. Persons are more vulnerable to air pollution if they have other illnesses or less social support. Harmful effects occur on a continuum of dosage and even at levels below air quality standards previously considered to be safe.

Fine Particulate Matter

It wasn’t that long ago that most of us had never heard of fine particulate matter, or FPM. It’s a term that first appeared in news reports surrounding the Volkswagen diesel cheating scandal. FPM emissions from diesel engines are significant, but they are a byproduct of burning all fossil fuels.

Some, like coal, create more. Some, like natural gas, create less. But all create some fine particulates. Whether its generating electricity, powering airplanes, or fueling cars, buses, trucks, and trains, fossil fuels fill the air with crud that is bad for us to breathe.

Research Is Hard

Research is hard to do on living humans. Many of the conclusions in the report are inferential. For instance, when Beijing shut down many of the more egregious sources of air pollution in the run-up to the Olympics in 2008, median birth weights in and around the city increased.

That makes it easy for fossil fuel apologists to attack the conclusions of reports such as this. Taking lessons learned from the tobacco industry, those who suck on the teat of Koch Industries and the American Petroleum Institute find it ridiculously easy to suggest that unless and until a particular FPM has been conclusively linked to a particular health issue, no action can be taken that would damage the economic interests of their clients.

That’s a little like saying that unless scientists can identify the particular photon that strikes the retina of a human eye as coming from the sun, dawn is just a theory. Such distortions have worked for more than half a century now. No need to abandon such tactics now when they are working so well.

Acute & Chronic Harm

“Air pollution can harm acutely, as well as chronically, potentially affecting every organ in the body,” the researchers conclude. “Ultrafine particles pass through the [lungs], are readily picked up by cells, and carried via the bloodstream to expose virtually all cells in the body.”

Prof Dean Schraufnagel, at the University of Illinois at Chicago and who led the reviews, tells The Guardian. “I wouldn’t be surprised if almost every organ was affected. If something is missing [from the review] it is probably because there was no research yet.”

The review represents “very strong science,” says Dr. Maria Neira, director of public and environmental health at the World Health Organization. “It adds to the very heavy evidence we have already. There are more than 70,000 scientific papers to demonstrate that air pollution is affecting our health. Issues like Parkinson’s or autism, for which there is some evidence but maybe not the very strong linkages, that evidence is coming now.”

The danger from FPM pollution is that those tiny particles are so small, they can cross directly into the bloodstream in the lungs. From there, they get transported to virtually every cell in the body. Unborn children are especially at risk as they are completely dependent upon the mother’s bloodstream for sustenance.

“Animal studies have shown they can even travel right up the olfactory nerve into the brain,” Schraufnagel saya. He adds that an emerging area of research suggests air pollution can affect how genes function as well. Strokes, dementia, and reduced intelligence are all conditions affecting the brain that have been linked to air pollution. Poor sleep can also be a consequence of breathing toxic air.

“Immune cells think a [pollution particle] is a bacteria, go after it and try to kill it by releasing enzymes and acids,” he explains. “Those inflammatory proteins spread into the body, affecting the brain, the kidneys, the pancreas and so forth. In evolutionary terms, the body has evolved to defend itself against infections, not pollution.”

Many doctors are unaware of the wide-ranging damage associated with air pollution, Schraufnagel says. “Some have no idea air pollution affects the organs they specialize in. But it affects their organs too and they had better pay attention. They need to educate their patients and then they should speak up in favor of action.”

The report warns that “Harmful effects occur even at levels below air quality standards previously considered to be safe. The good news is that the problem of air pollution can be addressed.” Schraufnagel says, “The best way to reduce exposure is to control it at its source.”

Addressing The Problem At Its Source

Since most air pollution comes from burning fossil fuels to generate electricity, heat homes and power transport, “We need to work on these factors in a very dramatic way,” Dr. Neira. “We are probably the first generation in history to be exposed to such a high level of pollution.

“People will say that in London or other places it was worse 100 years ago, but now we are talking about an incredible number of people exposed for a long time. We have megacities where all the citizens are breathing toxic air. However, with all the tons of evidence we are collecting now, politicians will not be able to say we didn’t know.”

Well, yes, Dr.Neira, that’s exactly what they will say, because that’s what those who fund their continued political careers will require them to say so in order to keep the flow of campaign dollars flowing.

The difference is that whereas before climate activists could only talk about some inchoate climate emergency, starving polar bears, and thinning ice shelves at the poles, now we can say “STOP POLLUTING OUR BODIES AND KILLING OUR CHILDREN!” Those are words that even the most feckless politician can understand.

The solution should be intuitively obvious to the most casual observer. Electrify everything with renewable energy and stop burning fossil fuels. D’uh.

**

February 2019 Volume 155, Issue 2, Pages 409–416
Air Pollution and Noncommunicable Diseases: A Review by the Forum of International Respiratory Societies’ Environmental Committee, Part 1: The Damaging Effects of Air Pollution
Dean E. Schraufnagel, MDa,∗,'Correspondence information about the author MD Dean E. SchraufnagelJohn R. Balmes, MDbClayton T. Cowl, MDc, Sara De Matteis, MD, MPH, PhDd
Soon-Hee Jung, MD, PhDe

Kevin Mortimer, MB, BChir, PhDf,

Rogelio Perez-Padilla, MDg

Mary B. Rice, MD, MPHh,

Horacio Riojas-Rodriguez, MD, PhDi

Akshay Sood, MD, MPHj,

George D. Thurston, ScDk

Teresa To, PhDl,

Anessa Vanker, MBChB, PhDm

Donald J. Wuebbles, PhDn

PlumX Metrics
DOI: https://doi.org/10.1016/j.chest.2018.10.042

Air pollution poses a great environmental risk to health. Outdoor fine particulate matter (particulate matter with an aerodynamic diameter < 2.5 μm) exposure is the fifth leading risk factor for death in the world, accounting for 4.2 million deaths and > 103 million disability-adjusted life years lost according to the Global Burden of Disease Report. The World Health Organization attributes 3.8 million additional deaths to indoor air pollution. Air pollution can harm acutely, usually manifested by respiratory or cardiac symptoms, as well as chronically, potentially affecting every organ in the body. It can cause, complicate, or exacerbate many adverse health conditions. Tissue damage may result directly from pollutant toxicity because fine and ultrafine particles can gain access to organs, or indirectly through systemic inflammatory processes. Susceptibility is partly under genetic and epigenetic regulation. Although air pollution affects people of all regions, ages, and social groups, it is likely to cause greater illness in those with heavy exposure and greater susceptibility. Persons are more vulnerable to air pollution if they have other illnesses or less social support. Harmful effects occur on a continuum of dosage and even at levels below air quality standards previously considered to be safe.

Key Words: air pollution, mechanism of damage, noncommunicable diseases

Abbreviations:CO (carbon monoxide), NO2 (nitrogen dioxide), O3 (ozone), PM0.1 (particulate matter with an aerodynamic diameter < 0.1 μm), PM2.5 (particulate matter with an aerodynamic diameter < 2.5 μm), PM10 (particulate matter with an aerodynamic diameter < 10 μm), SO2 (sulfur dioxide)

**

Exclusive: Comprehensive analysis finds harm from head to toe, including dementia, heart and lung disease, fertility problems and reduced intelligence

Damian Carrington, Environment editor, The Guardian, May 17, 2019

Air pollution may be damaging every organ and virtually every cell in the human body, according to a comprehensive new global review.

The research shows head-to-toe harm, from heart and lung disease to diabetes and dementia, and from liver problems and bladder cancer to brittle bones and damaged skin. Fertility, fetuses and children are also affected by toxic air, the review found.

The systemic damage is the result of pollutants causing inflammation that then floods through the body and ultrafine particles being carried around the body by the bloodstream.

Air pollution is a “public health emergency”, according to the World Health Organization, with more than 90% of the global population enduring toxic outdoor air. New analysis indicates 8.8m early deaths each year – double earlier estimates – making air pollution a bigger killer than tobacco smoking.

But the impact of different pollutants on many ailments remains to be established, suggesting well-known heart and lung damage is only “the tip of the iceberg”.

“Air pollution can harm acutely, as well as chronically, potentially affecting every organ in the body,” conclude the scientists from the Forum of International Respiratory Societies in the two review papers, published in the journal Chest. “Ultrafine particles pass through the [lungs], are readily picked up by cells, and carried via the bloodstream to expose virtually all cells in the body.”

Prof Dean Schraufnagel, at the University of Illinois at Chicago and who led the reviews, said: “I wouldn’t be surprised if almost every organ was affected. If something is missing [from the review] it is probably because there was no research yet.”

The review represents “very strong science”, said Dr Maria Neira, WHO director of public and environmental health: “It adds to the very heavy evidence we have already. There are more than 70,000 scientific papers to demonstrate that air pollution is affecting our health.”

She said she expected even more impacts of air pollution to be shown by future research: “Issues like Parkinson’s or autism, for which there is some evidence but maybe not the very strong linkages, that evidence is coming now.”

How air pollution reaches every part of the body …

The WHO has called air pollution the “silent killer” because its widespread effects are often not ascribed to toxic air.

Lungs and heart

The harmful effects of dirty air shown in the review begin when the pollution is inhaled.

This results in breathing problems, from asthma to emphysema to lung cancer. There is now overwhelming evidence that air pollution results in serious harm not only to the lungs, but also to the heart. Here it increases the risk of heart attacks as arteries narrow and muscles weaken.

One reason for the wide-ranging damage from air pollution is that very small particles can penetrate the lungs and be carried around the body. “They land in the organs directly,” Schraufnagel said.

“Animal studies have shown they can even travel right up the olfactory nerve into the brain.” An emerging area of research also suggests air pollution can affect how genes function, he added.

Brain and mind

Strokes, dementia and reduced intelligence are all conditions affecting the brain that have been linked to air pollution.

There is also evidence that poor sleep can be a consequence of breathing toxic air.

The main reason for the far-reaching damage from air pollution is systemic inflammation, said Schraufnagel.

“Immune cells think a [pollution particle] is a bacteria, go after it and try to kill it by releasing enzymes and acids,” he said.

“Those inflammatory proteins spread into the body, affecting the brain, the kidneys, the pancreas and so forth. In evolutionary terms, the body has evolved to defend itself against infections, not pollution.”

Abdominal organs

Among the many other organs affected is the liver. Schraufnagel said the latter surprised him, until he thought about the liver’s role in removing toxins from the body: “It makes perfect sense, but I would not have thought about it before starting the study.”

Research highlighted in the review also links air pollution to numerous cancers, including in the bladder and the gut, where an increase in irritable bowel syndrome has also been found.

Even skin and bones are affected, with skin ageing, hives and brittle bones associated with toxic air.

Reproduction, babies and children

Perhaps the most disturbing impact of toxic air is the damage to reproduction and children. Fertility is reduced and miscarriages increased by exposure to air pollution.

The unborn are also affected, with a recent study finding pollutants in the placentasthat nourish foetuses.

Air pollution is also strongly linked to low birthweights for babies, which has lifelong consequences.

Children are especially vulnerable, the review found, as their bodies are still developing.

Exposure to dirty air leads to stunted lungs, increases in childhood obesity, leukemia and mental health problems.

‘Doctors need to speak up’

Schraufnagel is concerned that many doctors are unaware of this wide-ranging damage associated with air pollution.

“Some have no idea air pollution affects the organs they specialise in. But it affects their organs too and they had better pay attention,” he said. “They need to educate their patients and then they should speak up” in favour of action.

Researchers cannot experiment on people and so by necessity many studies show significant associations between poor air quality and disease, but cannot prove cause and effect.

However, Schraufnagel said particularly compelling evidence comes from three types of study: where air pollution and illness change in tandem over time, where the “dose” of pollution correlates with levels of disease and from animal studies.

For example, government action to slash pollution before the Beijing Olympics in 2008 led to a rise in birth weights in the city.

“Harmful effects occur even at levels below air quality standards previously considered to be safe,” warn the review scientists, who between them represent every continent. But they add: “The good news is that the problem of air pollution can be addressed.”

“The best way to reduce exposure is to control it at its source,” said Schraufnagel. Most air pollution comes from burning fossil fuels to generate electricity, heat homes and power transport.

“We need to work on these factors in a very dramatic way,” said Neira. “We are probably the first generation in history to be exposed to such a high level of pollution. People will say that in London or other places it was worse 100 years ago, but now we are talking about an incredible number of people exposed for a long time.”

“We have megacities where all the citizens are breathing toxic air,” she said. “However, with all the tonnes of evidence we are collecting now, politicians will not be able to say we didn’t know.”

• What you – and your government – can do about air pollution

• Air pollution: everything you should know about a public health emergency

Global Burden of Disease ReportPublished in The Lancet in November 2018, GBD 2017 provides for the first time an independent estimation of population, for each of 195 countries and territories and the globe, using a standardized, replicable approach, as well as a comprehensive update on fertility. GBD 2017 incorporates major data additions and improvements, and methodological refinements.

Mortality and life expectancy estimates have been extended back to 1950, and new causes have been added to the fatal and non-fatal cause lists, for a total of 359 diseases and injuries. One new risk factor, bullying victimization, and 80 new risk-outcome pairs have also been added. More SDG indicators are now examined, and forecasting methods are used to generate projections through 2030 and assess the pace of change needed to attain the SDGs. Produced with the input of 3,676 collaborators from 146 countries and territories, GBD 2017 also includes estimates at the subnational level for Russia in addition to the countries for which subnational estimates have been published in previous editions of the GBD study (Brazil, China, India, Indonesia, Japan, Kenya, Mexico, South Africa, Sweden, the UK, and the US).

This page summarizes all available resources from the capstone publications of the Global Burden of Disease (GBD) 2017 study.

Baby ‘Boom’ and ‘Bust’: Nations’ Rates of Childbirth Vary Significantly

CAPSTONE RESEARCH ARTICLES

Full articles are available for download at The Lancet: https://www.thelancet.com/gbd

Population and Fertility

Mortality

Causes of Death

Years Lived with Disability (YLDs)

Disability-Adjusted Life Years (DALYs)

Risk Factors

Sustainable Development Goals (SDGs)

DOWNLOAD THE DATA: Download all estimates and find other data-related resources associated with GBD 2017 publications on the Global Health Data Exchange (GHDx): http://ghdx.healthdata.org/gbd-2017

GBD Results Tool: This query tool allows download of full GBD results data in CSV format.

What’s included:

  • All GBD causes, risks, etiologies, impairments, injuries by nature, and sequela aggregates
  • Measures: deaths, years of life lost (YLLs), years lived with disability (YLDs), disability-adjusted life years (DALYs), prevalence, incidence, life expectancy, probability of death, healthy life expectancy (HALE), maternal mortality ratio (MMR), and summary exposure value (SEV)
  • Metrics (units): number, rate, percent, years, probability of death
  • Years: 1990-2017; annual results for all measures
  • All GBD age groups
  • Sexes: males, females, both sexes
  • Locations: GBD super-regions, regions, countries, select subnational units, and custom regions (WHO regions, World Bank Income Levels, and more)

Data Input Sources Tool

The Data Input Sources Tool allows users to explore GBD 2017 input data sources and retrieve relevant metadata.

DATA VISUALIZATIONS

Use these visualizations to interact with the latest GBD 2017 estimates, comparing causes, injuries, and risks across time, age, and place.

GBD Compare

Analyze updated data about the world’s health levels and trends from 1990 to 2017 in this interactive tool using estimates from the GBD study.

Health-related SDGs Viz

With this tool, users can explore progress made toward achieving the United Nations Sustainable Development Goals (SDGs). Measure progress made by 195 countries from 1990 to 2017 toward 41 health-related indicators.

Mortality Viz

Walk through the estimation process for mortality trends for children and adults for 195 countries and territories using the revamped Mortality visualization.

CoD Viz

You can examine more than 282 causes in both adjusted and pre-adjusted numbers, rates, and percentages for 195 countries and territories with this tool.

Epi Viz

With this interactive tool, you can explore data inputs and epidemiological estimates from the GBD 2017 project.

COUNTRY PROFILES

The Country Profiles provide an overview of findings from the Global Burden of Disease (GBD). They are based on over 80,000 different data sources used by researchers to produce the most scientifically rigorous estimates possible. These profiles are meant to be freely downloaded and distributed.

STUDY HIGHLIGHTS

Explore key findings, global trends, what’s new, and important highlights for each of the seven GBD 2017 studies.

Population and Fertility

Life Expectancy and Mortality

Causes of Death

Years-Lived with Disability (YLDs)

Disability-Adjusted Life Years (DALYs)

Risk Factors

Sustainable Development Goals (SDGs)

PRESENTATION

Global Burden of Disease (GBD) 2017 study findings

Introduction

Air pollution may be the greatest environmental risk to health in the world.1 According to the Global Burden of Disease estimates, one component of ambient (or outdoor air) pollution, fine particulate matter, or particulate matter with an aerodynamic diameter < 2.5 μm (PM2.5), is the fifth leading risk factor for death in the world, accounting for 4.2 million deaths (7.6% of total global deaths) and > 103 million disability-adjusted life years lost in 2015. Exposure to ambient ozone (O3) caused an additional 254,000 deaths,2 and estimates based on other statistical techniques set these numbers even higher.3 The World Health Organization reported that indoor air pollution from fires for cooking and heating accounted for 3.8 million deaths; this number ranged from 10% in low- and middle-income countries to 0.2% in high-income countries.4 In almost all cases, the greatest affliction of air pollution falls on the vulnerable population.

Air pollution may be associated with symptoms immediately upon exposure, such as coughing, tearing, difficulty breathing, and angina. It may also be associated with long-term harm that is more subtle. People are usually unaware of how long-term exposure affects their health or worsens their medical problems over time. Polluted air gains access to the body through the respiratory tract but has systemic effects that can damage many other organs.

The main purpose of these two papers is to review the available evidence to support the hypothesis that air pollution affects many organs beyond the lungs. The review omits infectious diseases and tobacco smoke exposure, and it generally does not distinguish between ambient and indoor (household) air pollution, although they can have very different compositions. Tobacco smoke could be considered a form of high-dose air pollution. There are similarities between tobacco smoke and air pollution in how they injure the body; in addition, their harmful health effects become increasingly similar as the toxicity and dosages of the inhaled materials become more alike. However, the lung disease resulting from exposure to indoor smoke has more bronchitic elements and fewer emphysematous elements than tobacco smoking.5 In Part 1 of this report, we review the mechanisms and multisystem health effects of air pollution in general and among vulnerable populations. In Part 2,6 we review the evidence for air pollution’s effects on individual organ systems.

What Air Pollution Is and How It Causes Illness

Air pollution is defined as any substance in the air that may harm humans, animals, vegetation, or materials.7 Pollutants come from various sources, and each can have differing characteristics depending on the composition, source, and conditions under which they were produced. Common gases include the sulfur oxides (mainly sulfur dioxide [SO2]), nitrogen oxides (mainly nitric oxide and nitrogen dioxide [NO2]), reactive hydrocarbons (often referred to as volatile organic compounds), and carbon monoxide (CO). They are released directly into the atmosphere, usually from industrial or transportation sources, and are called “primary pollutants.” Gaseous and particle pollutants can also form in the atmosphere, largely from the primary pollutants and are called “secondary pollutants.” For example, O3 is formed from nitrogen oxides and hydrocarbons in the atmosphere; sulfuric acid is produced from atmospheric sulfur; and ammonium nitrate aerosols are created from atmospheric nitrogen oxide gases.

The damage to human tissue by gases depends on their water solubility, concentration, ability to oxidize tissue, and the affected person’s susceptibility. SO2 is highly soluble in water and largely damages the upper airways and skin, whereas NO2 and O3 are less soluble and therefore can penetrate deeper into the lung. CO is highly soluble and nonirritating and readily passes into the bloodstream. Its toxicity mainly results from successfully competing with oxygen in binding to hemoglobin, which results in tissue hypoxia. Its effects are acute: a 2-day increase of mean CO levels of 1 mg/m3 was associated with a 1.2% increase in total deaths in a large European study.8 Nitric oxide also attaches to hemoglobin and other iron-containing proteins, but it generally acts only a short distance from its contact point because of its binding affinity.

PM is usually classified by its size or aerodynamic diameter; PM10 denotes particles < 10 μm in diameter; PM2.5 particles are < 2.5 μm in diameter; and PM0.1 particles are < 0.1 μm in diameter. All PM2.5 and PM0.1are included in PM10. Therefore, adverse effects attributed to PM10 could be caused by smaller particles. The term “coarse particles” is used to refer to particulates between PM10 and PM2.5 in size. In contrast to large particles that can be visible as dust or haze with appropriate lighting, small particles are invisible. Large particles may affect mucous membranes and the upper airways, causing cough and tearing. Fine particles (PM2.5) easily find their way into lung alveoli, and ultrafine particles (PM0.1) pass through the alveolar-capillary membrane, are readily picked up by cells, and carried via the bloodstream to expose virtually all cells in the body. Smaller particles, therefore, have greater systemic toxicity (Table 1).

Table 1How Different Types of Air Pollution Damage Tissue
Pollutant Injury Determinants Tissue Affected
Sulfur dioxide Highly soluble Upper airway and skin damage
Nitrogen dioxide

Ozone

Carbon monoxide

 Less soluble (nitrogen dioxide and ozone are irritating) Deeper lung penetration

Bronchial and bronchiolar injury

Carbon monoxide: tissue hypoxia
Particulate matter (PM10, PM2.5, PM0.1) Size, structure, and composition determine toxicity Large particles: mucous membranes, upper airways

Small particles: bronchioles and alveoli

Ultrafine particles: systemic tissue reactions

View Table in HTML

PM0.1 = particulate matter with an aerodynamic diameter < 0.1 μm; PM2.5 = particulate matter with an aerodynamic diameter < 2.5 μm; PM10 = particulate matter with an aerodynamic diameter < 10 μm.

Beyond its size, the harm caused by PM relates to its structure and composition. For example, particles that are highly acidic are more noxious. Toxic components may lie on the particle’s surface and be responsible for the tissue damage on contact. Toxic “hitchhikers,” elements such as arsenic, lead, or cadmium, or compounds such as sulfuric acid or polycyclic aromatic hydrocarbons, can be picked up during the combustion process and be carried deep into the lung on the surface of the ultrafine particles. This scenario is most relevant to particles resulting from fossil fuel combustion, especially coal combustion, which contains many heavy metal constituents and high levels of sulfur. If similar-sized particles do not contain as many toxic add-ons, they generally cause less harm.9 PM, however, can also interact with airborne allergens as hapten carriers to trigger or even induce allergic asthma reactions in sensitized subjects.10

In addition to encroaching on an organ and causing direct harm, exposure to pollutants, including toxic metals, organic compounds, and gases, can cause inflammation with systemic effects. The inflammation, usually in the lung, causes oxidative stress. Oxidative stress entails lipid peroxidation, depletion of antioxidants, and activation of pro-inflammatory signaling. The pro-inflammatory signaling sets off a cascade of events that may affect distant organs. The greater the surface area of ultrafine particles, the greater the ability to produce oxidative stress.11 Increases in particulate exposure are associated with elevated C-reactive protein, fibrinogen, circulating blood leukocytes and platelets, and plasma viscosity.12Leukocytes, adhesion proteins, clotting proteins, and an array of cytokines and inflammatory mediators tax the endothelium, which may lose its modulating function.13 Repeated insults from pollution can contribute to vascular conditions, such as atherosclerosis, and can have a wide range of effects on metabolism. Ultrafine particles that go directly into different organs also can be responsible for inflammation in that organ.14

In addition, the lung faces the damaging effects of filtering PM and accumulation of “soot” in the lungs if the clearance mechanisms cannot handle the load. The sheer volume of PM may overwhelm macrophage function and the lymphatic system, leaving deposits of material centered around the terminal bronchioles and early-generation respiratory bronchioles (Fig 1).15 The particulate burden may lead to chronic focal inflammation and fibrosis, and could predispose to “scar” lung carcinoma.16 The efficiency of particulate clearance is a factor in how pollution affects the body.

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Figure 1

Anthracotic lung. Inhaled particulates are usually cleared through the respiratory mucociliary apparatus and scavenged by alveolar macrophages. Particles can move into the interlobular septal lymphatics and be cleared by the lymphatic system, but if these mechanisms are overwhelmed, particulates may clog lymphatics and be deposited in the lung interstitium. Ultrafine particles gain entrance to mobile cells and can be transported to all parts of the body. Although this anthracotic lung is characteristic of smokers and workers in dusty occupations, anthracotic deposits are often found in urban dwellers from air pollution.

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The immune and inflammatory responses to air pollutants may be genetically regulated. Many important genes involve inflammation and variation in glutathione synthesis.17 Genetic variation in the glutathione pathway reportedly increases susceptibility to pollution-related lung function decrements in children.18Variations in genes that control inflammatory mediators, which include Toll-like receptor 4, tumor necrosis factor-α, transforming growth factor-β, and many others, have been found to increase susceptibility to the respiratory effects of pollution.17 Air pollutants affect both the innate and adaptive immune systems. PM disturbs the balance of the Th1 and Th2 leukocyte populations, resulting in dominant Th2 leukocytes, which is a feature of asthma.19

Epigenetics refers to potentially reversible modifications to DNA that control how genes are expressed, without altering the DNA sequence. Epigenetics mediate genetic and physiologic responses to air pollution and are, therefore, an important cause of susceptibility to pollution-related health effects.20 Changes in microRNA and other RNA species also regulate gene expression, often through signaling pathways. Air pollution exposure may affect these epigenetic processes.21 Cord blood samples from several birth cohort studies showed that prenatal NO2 exposure was associated with DNA methylation in several mitochondria-related genes, as well as in several genes involved in antioxidant defense pathways.22 Figure 2 illustrates the different ways in which air pollution can mediate tissue damage.

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Figure 2

Pollution damage by systemic inflammation. This scanning electron micrograph of the terminal and respiratory bronchioles are the sites where most material accumulates, making it the area of the lung most vulnerable to pollution. In addition, this figure depicts four ways that pollution can affect all organs through systemic inflammation. Ultrafine particles pass through the alveolar-capillary membrane, are endocytosed, and distributed throughout the body. They induce similar inflammatory reactions in other organs. (Copyright reserved Dean Schraufnagel.)

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Air Pollution and Exercise

Physical exertion that results in increased ventilation and mouth breathing augments inhalation of air pollutants. In athletes who stress their ventilatory and cardiac reserves, pollution exposure has been found to decrease exercise performance. Maximal oxygen consumption and exercise duration are decreased with exposure to CO.23 Experimental exposure to O3 reduces the exercise capacity of athletes and leads to a transient decrease in spirometric function.24 Increased ambient PM10 concentrations are associated with reduced marathon performance in women.25 Despite these harmful effects, studies suggest that the health benefits of exercise outweigh the adverse effects of pollution exposure during exercise26 in all but the most polluted areas.27

Sleep

Sleep efficiency is decreased in most polluted areas, especially with increased exposure to NO2 and PM.28Several studies show that air pollution is associated with increased sleep apnea symptoms, possibly because of upper airway inflammation from irritant pollutants and airborne allergens29 and household biomass smoke.30

Air pollution may affect sleep adversely in other ways. Traffic-related air pollution is highest near busy streets, which confounds sleep studies because the environment is more often noisy and illuminated. Pollution may also disturb sleep by exacerbating asthma, COPD, or other respiratory or chronic diseases. In addition, pollutants may lead to an inflammatory reaction in the CNS or directly interfere with neuronal function that may affect sleep.31

Children

Children are especially harmed by air pollution for both environmental and biologic reasons. Children breathe more air per unit body weight and, therefore, inhale more airborne toxicants than adults exposed to the same amount of air pollution. In many parts of the world where biomass is burned indoors for cooking and heating, small children are heavily exposed to indoor air pollution along with their mothers. Children all over the world generally spend more time outdoors and are more physically active than adults, which can result in greater exposure to outdoor air pollution.

Children are biologically more susceptible to pollution because their bodies are still not mature. Lung and immune system development occurs over the entire prenatal period, beginning with embryogenesis and continuing for many years after birth. Infants are born with only about 20% of the alveoli that they will eventually make once they have reached adulthood. Exposures to air pollutants during the prenatal period and during childhood can have harmful and irreversible effects on the lung and other organ systems.

Postnatal exposures to air pollutants, including PM, O3, and NO2, have been associated with increased infant mortality, even in developed countries such as the United States. The strongest associations have been with postneonatal respiratory mortality,32, 33, 34 which in part may be related to respiratory infections that have links to pollution.35 Air pollution may be a “second hit” in newborns who are susceptible to infection because of their immature immune systems. Postnatal diesel pollution exposure also has been found to attenuate the lung’s immune response to respiratory infection and to augment the inflammatory response, which likely results in a worse course of illness.36

Air pollution has also been found to affect growth trajectories of the lung and its function during childhood, which can affect the level of respiratory health achieved in adulthood. PM2.5 exposure reportedly impairs prenatal and postnatal development of the tracheobronchial tree.37 Many studies have found that higher exposure to PM and traffic are linked to worse lung function in childhood, and slower child lung function growth,38, 39, 40 which, in turn, may limit lung function in adulthood.41 Long-term exposure to pollution during childhood, especially traffic-related pollution, has been associated with the risk of developing childhood asthma42, 43 and is another example of how pollution exposure during childhood affects organ development and risk of subsequent chronic disease.

Maternal-Fetal Health and Reproductive Health

Exposure to air pollution during pregnancy is associated with adverse pregnancy outcomes and reduced fetal growth. A review of > 13,000 pregnancies in Scotland found that exposure to higher levels of PM2.5, PM10, and NO2 were associated with lower infant head size during pregnancy and at birth.44 Another study across all trimesters of pregnancy reported that the risk of intrauterine growth restriction was increased among women exposed to higher levels of CO, NO2, and PM2.5.45 A meta-analysis that included nearly 3 million births across 14 centers from nine developed countries found that, after adjusting for socioeconomic status, maternal exposure to particulate air pollution was associated with a higher risk of low birth weight infants.46

Although many studies measure air pollution exposures over the entire course of pregnancy, it is believed that exposure in the first trimester of pregnancy poses a greater risk than subsequent exposures. A study of nearly 30,000 term single births in Japan found that exposure to pollutants over the course of the entire pregnancy was not associated with fetal growth restriction. However, when they examined exposures in the first trimester, O3 exposure was associated with higher odds of small for gestational age and low birth weight infants.47 Another study of > 5,000 mother-child pairs of the Boston Birth Cohort found that women who were exposed to the highest levels of PM were more likely to have intrauterine inflammation48compared with those exposed to the lowest levels. The risk was highest for exposures measured in the first trimester of pregnancy.

Air pollution increases the risk of preterm birth and low birth weight independently and additively to other known risk factors, such as lower socioeconomic status, diabetes, hypertension, and smoking.49 Women who are exposed to higher levels of traffic-related air pollution during pregnancy may be at increased risk of preeclampsia, which may be one mechanism explaining the association with preterm birth.50 Also, increased exposure to O3 and PM2.5 within 5 h of delivery has been linked to higher risk of premature rupture of membranes, which predisposes women to preterm delivery.51 These adverse effects on pregnancy and birth outcomes have been observed even at relatively low levels of air pollution exposure. They are especially concerning because preterm birth, low birth weight, and small for gestational age infants are at increased risk of a variety of health problems, including reduced lung growth and cognitive problems, that can persist for their lifetimes. Conversely, reducing air pollution has prompt benefits. When measures were taken to effectively reduce air pollution during the 2008 Beijing Olympic Games, there was an improvement in infant birth weight in association with the reduction in NO2, a marker of traffic-related air pollution.52

Fertility

Several studies have found that air pollution is associated with reduced fertility rates and increased risk of miscarriage. A Mongolian study found a dose-dependent relationship between the monthly average SO2, NO2, CO, PM10, and PM2.5 levels during pregnancy and risk of spontaneous abortions.53 A few studies have shown or suggested that semen or sperm quality is decreased in areas of high pollution.54, 55

Vulnerable Populations

Although air pollution affects people of all regions, ages, and social and economic groups, it is more likely to cause ill health and death in certain individuals. Exposures to air pollution and other environmental factors and biological susceptibility are the most important factors determining response. People living in Africa, Asia, and the Middle East on average breathe higher levels of pollutants than those in other parts of the world1 and, therefore, sustain a greater health burden.

Both extrinsic and intrinsic factors determine vulnerability to adverse health effects from exposures to air pollution. The most important is the level of exposure. People of low social and economic status often have greater exposures to air pollution because they live in areas of greater traffic density and near point sources of pollution such as power plants and industrial facilities. Other extrinsic neighborhood factors that contribute to vulnerability include poor housing, the lack of stores to purchase healthy food (eg, fruits and vegetables that contain antioxidants), violent crime, segregation, lack of green space, and poor access to health care.56 Poorer people are also more likely to work in “dirty” jobs with occupational exposures to vapors, dusts, gases, and fumes.57 Intrinsic factors that increase vulnerability to air pollution include age (very young and very old), preexisting disease, pregnancy, genetic and epigenetic variation, smoking, and obesity.58, 59 The concept of cumulative risk combines both extrinsic and intrinsic factors when attempting to assess the vulnerability of an individual or a population to the ill effects of air pollution.

When factors are combined, the effects can be additive or multiplicative. For example, preexisting cardiopulmonary diseases and diabetes increase susceptibility to the effects of particulate air pollution.59Psychosocial stress interacts with exposure to traffic-related air pollution to increase the risk of new-onset asthma in children.60, 61 It may also enhance the effects of particulate pollution on BP.62 The association between air pollution and cancer risk has been shown to be greater in neighborhoods with higher levels of ethnic minority segregation, an indicator that may capture the cumulative impact of multiple adverse social and psychosocial exposures.63

Impoverished individuals, especially ethnic minorities, are more likely to live in segregated neighborhoods that are near sources of pollution and busy roadways. Consequently, these individuals are more often exposed to higher concentrations of outdoor air pollutants than persons with higher economic status.59They are also likely to have greater cumulative health risks from other detrimental neighborhood factors. In low-income countries, women, small children, and rural residents are likely to be exposed to higher concentration of household air pollutants during cooking and heating activities.64

Vulnerability is made worse by health inequality and environmental injustice.65 Proponents of environmental justice argue that investigators and regulatory agencies should evaluate the cumulative impacts of environmental and social stressors in research studies and regulatory policies. Pollutant and source-specific assessments of potential health risks of air pollution do not inherently reflect the multiple environmental and social stressors faced by vulnerable communities that can interact to harm health. Reducing vulnerability across a population calls for reducing poverty, segregation, and health-damaging neighborhood environmental factors as well as reducing the ambient levels of pollutants. Strategies to achieve health equality for vulnerable communities require societal commitment of resources as well as the promulgation of air quality control measures.66

Acknowledgments

Financial/nonfinancial disclosures: None declared.

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FUNDING/SUPPORT: The contribution by G. D. T. was supported in part by a National Institute of Environmental Health Sciences Center grant [Grant E500260] to the New York University School of Medicine.

© 2018 Published by Elsevier Inc under license from the American College of Chest Physicians.